Drug interactions
Cyclosporin + Pentobarbital
Severity: Moderate
Cyclosporin and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic CYP3A4 and can substantially lower cyclosporine concentrations. This may lead to subtherapeutic immunosuppression and graft rejection.
What this interaction means in plain words
Cyclosporin and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated cyclosporine metabolism by pentobarbital.
What to do
Monitor cyclosporine trough levels and increase the dose as needed; reduce it again when pentobarbital is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Pentobarbital?
MediHelp rates the interaction as moderate. Cyclosporin and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic CYP3A4 and can substantially lower cyclosporine concentrations. This may lead to subtherapeutic immunosuppression and graft rejection.
How serious is the interaction between Cyclosporin and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and increase the dose as needed; reduce it again when pentobarbital is stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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