Drug interactions
Cyclosporin + Pneumococcal vaccine heptavalent
Severity: Moderate
Cyclosporin and Pneumococcal vaccine heptavalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin can reduce antibody responses to pneumococcal conjugate vaccine, potentially giving less durable protection against pneumococcal disease in an already susceptible patient.
What this interaction means in plain words
Cyclosporin and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell activation and T-dependent antibody responses to vaccine antigens.
What to do
Vaccinate ideally at least 2 weeks before starting immunosuppression, and do not delay vaccination in patients already treated. Follow the local schedule for additional doses or revaccination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Pneumococcal vaccine heptavalent, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Pneumococcal vaccine heptavalent?
MediHelp rates the interaction as moderate. Cyclosporin and Pneumococcal vaccine heptavalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin can reduce antibody responses to pneumococcal conjugate vaccine, potentially giving less durable protection against pneumococcal disease in an already susceptible patient.
How serious is the interaction between Cyclosporin and Pneumococcal vaccine heptavalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before starting immunosuppression, and do not delay vaccination in patients already treated. Follow the local schedule for additional doses or revaccination.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
