Drug interactions
Cyclosporin + Poliovirus vaccine inactivated
Severity: Moderate
Cyclosporin and Poliovirus vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may reduce the antibody response to inactivated poliovirus vaccine, so immunity may be lower than expected. Inactivated vaccine is still the appropriate choice in immunosuppressed patients.
What this interaction means in plain words
Cyclosporin and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell activation and T-dependent antibody responses to vaccine antigens.
What to do
Vaccinate ideally at least 2 weeks before starting immunosuppression, and give the inactivated vaccine rather than live oral vaccine. Consider checking serology or revaccinating if protection is uncertain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Poliovirus vaccine inactivated?
MediHelp rates the interaction as moderate. Cyclosporin and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may reduce the antibody response to inactivated poliovirus vaccine, so immunity may be lower than expected. Inactivated vaccine is still the appropriate choice in immunosuppressed patients.
How serious is the interaction between Cyclosporin and Poliovirus vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally at least 2 weeks before starting immunosuppression, and give the inactivated vaccine rather than live oral vaccine. Consider checking serology or revaccinating if protection is uncertain.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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