Drug interactions
Cyclosporin + Ponatinib
Severity: Moderate
Cyclosporin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein and may increase exposure to cyclosporine, a P-gp substrate. This could heighten cyclosporine toxicity such as nephrotoxicity.
What this interaction means in plain words
Cyclosporin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Ponatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by ponatinib increases cyclosporine absorption and reduces its elimination.
What to do
Monitor cyclosporine trough levels and renal function, and reduce the cyclosporine dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ponatinib
Frequently asked questions
Can I take Cyclosporin with Ponatinib?
MediHelp rates the interaction as moderate. Cyclosporin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-glycoprotein and may increase exposure to cyclosporine, a P-gp substrate. This could heighten cyclosporine toxicity such as nephrotoxicity.
How serious is the interaction between Cyclosporin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and reduce the cyclosporine dose if levels rise.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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