Drug interactions
Cyclosporin + Quercetin
Severity: Minor
Cyclosporin and Quercetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin may alter P-glycoprotein activity and has been reported to change cyclosporine absorption, with inconsistent direction of effect. Cyclosporine concentrations could therefore vary unpredictably.
What this interaction means in plain words
Cyclosporin and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Modulation of intestinal P-glycoprotein and possibly CYP3A4 by quercetin; the net effect is not well established.
What to do
Avoid starting or stopping quercetin supplements without checking cyclosporine trough levels, and monitor levels if use is continued.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Quercetin?
MediHelp rates the interaction as minor. Cyclosporin and Quercetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quercetin may alter P-glycoprotein activity and has been reported to change cyclosporine absorption, with inconsistent direction of effect. Cyclosporine concentrations could therefore vary unpredictably.
How serious is the interaction between Cyclosporin and Quercetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting or stopping quercetin supplements without checking cyclosporine trough levels, and monitor levels if use is continued.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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