Drug interactions
Cyclosporin + Quinapril
Severity: Moderate
Cyclosporin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce efferent arteriolar tone and cyclosporine constricts the afferent arteriole, which can lower glomerular filtration. Both also promote hyperkalemia, so the combination raises risk of acute kidney injury and elevated potassium.
What this interaction means in plain words
Cyclosporin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive renal hemodynamic effects and additive potassium retention.
What to do
Monitor serum creatinine and potassium at initiation and after dose changes, and reduce or stop quinapril if renal function or potassium worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Quinapril?
MediHelp rates the interaction as moderate. Cyclosporin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors reduce efferent arteriolar tone and cyclosporine constricts the afferent arteriole, which can lower glomerular filtration. Both also promote hyperkalemia, so the combination raises risk of acute kidney injury and elevated potassium.
How serious is the interaction between Cyclosporin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and potassium at initiation and after dose changes, and reduce or stop quinapril if renal function or potassium worsens.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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