Drug interactions
Cyclosporin + Rabies vaccine
Severity: Moderate
Cyclosporin and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine suppresses T-cell function and can blunt the antibody response to rabies vaccination. This may leave the patient with inadequate protection after exposure or travel.
What this interaction means in plain words
Cyclosporin and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition impairs T-cell dependent immune responses needed for vaccine immunogenicity.
What to do
Where feasible, vaccinate before starting cyclosporine; if vaccinated during therapy, check rabies neutralizing antibody titers and revaccinate if inadequate. Post-exposure prophylaxis should not be delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Rabies vaccine?
MediHelp rates the interaction as moderate. Cyclosporin and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine suppresses T-cell function and can blunt the antibody response to rabies vaccination. This may leave the patient with inadequate protection after exposure or travel.
How serious is the interaction between Cyclosporin and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, vaccinate before starting cyclosporine; if vaccinated during therapy, check rabies neutralizing antibody titers and revaccinate if inadequate. Post-exposure prophylaxis should not be delayed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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