Drug interactions
Cyclosporin + Romidepsin
Severity: Moderate
Cyclosporin and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein, which are involved in romidepsin disposition. Romidepsin exposure may increase, heightening risk of myelosuppression, nausea and ECG changes.
What this interaction means in plain words
Cyclosporin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of romidepsin by cyclosporine.
What to do
Monitor blood counts, electrolytes and ECG, and watch for romidepsin toxicity, with dose modification if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Romidepsin?
MediHelp rates the interaction as moderate. Cyclosporin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-glycoprotein, which are involved in romidepsin disposition. Romidepsin exposure may increase, heightening risk of myelosuppression, nausea and ECG changes.
How serious is the interaction between Cyclosporin and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, electrolytes and ECG, and watch for romidepsin toxicity, with dose modification if adverse effects occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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