Drug interactions
Cyclosporin + Ropeginterferon alfa 2b
Severity: Moderate
Cyclosporin and Ropeginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can suppress cytochrome P450 activity during inflammatory states, which may raise levels of narrow-therapeutic-index drugs like cyclosporine. Increased cyclosporine exposure could cause nephrotoxicity.
What this interaction means in plain words
Cyclosporin and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Interferon-mediated downregulation of CYP450 enzymes reduces cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels and renal function when starting, adjusting or stopping ropeginterferon, and adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Ropeginterferon alfa 2b?
MediHelp rates the interaction as moderate. Cyclosporin and Ropeginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can suppress cytochrome P450 activity during inflammatory states, which may raise levels of narrow-therapeutic-index drugs like cyclosporine. Increased cyclosporine exposure could cause nephrotoxicity.
How serious is the interaction between Cyclosporin and Ropeginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when starting, adjusting or stopping ropeginterferon, and adjust the cyclosporine dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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