Drug interactions
Cyclosporin + Rotavirus oral vaccine live
Severity: Major
Cyclosporin and Rotavirus oral vaccine live: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotavirus vaccine is live attenuated, and in immunosuppressed patients the vaccine virus may cause prolonged or severe gastroenteritis. Cyclosporin may also reduce the protective response.
What this interaction means in plain words
Cyclosporin and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Calcineurin inhibition impairs immunity needed to control replication of the live vaccine virus.
What to do
Avoid rotavirus vaccine in patients on cyclosporin, including infants exposed to maternal immunosuppression where specialist guidance advises deferral. Reassess vaccination eligibility with an immunologist or transplant specialist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Rotavirus oral vaccine live?
MediHelp rates the interaction as major. Cyclosporin and Rotavirus oral vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rotavirus vaccine is live attenuated, and in immunosuppressed patients the vaccine virus may cause prolonged or severe gastroenteritis. Cyclosporin may also reduce the protective response.
How serious is the interaction between Cyclosporin and Rotavirus oral vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rotavirus vaccine in patients on cyclosporin, including infants exposed to maternal immunosuppression where specialist guidance advises deferral. Reassess vaccination eligibility with an immunologist or transplant specialist.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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