Drug interactions
Cyclosporin + Sacubitril / valsartan
Severity: Moderate
Cyclosporin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine and valsartan both promote potassium retention, so combined use may cause hyperkalemia. Cyclosporine may also inhibit OATP transporters and increase sacubitril metabolite exposure, and renal function may decline.
What this interaction means in plain words
Cyclosporin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemic and renal hemodynamic effects, with possible OATP-mediated increase in sacubitril exposure.
What to do
Monitor serum potassium, creatinine and blood pressure regularly, particularly after initiation or dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Cyclosporin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine and valsartan both promote potassium retention, so combined use may cause hyperkalemia. Cyclosporine may also inhibit OATP transporters and increase sacubitril metabolite exposure, and renal function may decline.
How serious is the interaction between Cyclosporin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure regularly, particularly after initiation or dose changes.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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