Drug interactions
Cyclosporin + Salicylates
Severity: Moderate
Cyclosporin and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates inhibit prostaglandin synthesis and may enhance cyclosporine-related renal vasoconstriction. This can increase the risk of reduced kidney function.
What this interaction means in plain words
Cyclosporin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin inhibition combined with cyclosporine-induced renal vasoconstriction produces additive nephrotoxicity.
What to do
Monitor serum creatinine and blood pressure, and use the lowest effective salicylate dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Salicylates?
MediHelp rates the interaction as moderate. Cyclosporin and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates inhibit prostaglandin synthesis and may enhance cyclosporine-related renal vasoconstriction. This can increase the risk of reduced kidney function.
How serious is the interaction between Cyclosporin and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and blood pressure, and use the lowest effective salicylate dose for the shortest duration.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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