Drug interactions
Cyclosporin + Selumetinib
Severity: Major
Cyclosporin and Selumetinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine is a CYP3A4 inhibitor and can increase selumetinib concentrations. This raises the risk of selumetinib toxicities such as gastrointestinal effects, rash, and cardiomyopathy.
What this interaction means in plain words
Cyclosporin and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Selumetinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated metabolism of selumetinib.
What to do
Avoid if possible; otherwise reduce the selumetinib dose per its labeling and monitor for adverse effects. Restore the original dose about three half-lives after stopping the inhibitor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Selumetinib
Frequently asked questions
Can I take Cyclosporin with Selumetinib?
MediHelp rates the interaction as major. Cyclosporin and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine is a CYP3A4 inhibitor and can increase selumetinib concentrations. This raises the risk of selumetinib toxicities such as gastrointestinal effects, rash, and cardiomyopathy.
How serious is the interaction between Cyclosporin and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the selumetinib dose per its labeling and monitor for adverse effects. Restore the original dose about three half-lives after stopping the inhibitor.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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