Drug interactions
Cyclosporin + Smallpox and monkeypox vaccine live nonreplicating
Severity: Moderate
Cyclosporin and Smallpox and monkeypox vaccine live nonreplicating: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This vaccine uses a non-replicating modified vaccinia strain, so it carries much less risk of vaccine-virus infection than replicating smallpox vaccines. Cyclosporin may still reduce the immune response, and vaccination is often considered acceptable when exposure risk is significant.
What this interaction means in plain words
Cyclosporin and Smallpox and monkeypox vaccine live nonreplicating can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcineurin inhibition reduces T-cell-dependent immune responses and may blunt vaccine immunogenicity.
What to do
Vaccination can be considered in immunosuppressed patients at risk of exposure, accepting that the response may be reduced. Consider additional doses or serologic assessment per local public health guidance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Smallpox and monkeypox vaccine live nonreplicating?
MediHelp rates the interaction as moderate. Cyclosporin and Smallpox and monkeypox vaccine live nonreplicating can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This vaccine uses a non-replicating modified vaccinia strain, so it carries much less risk of vaccine-virus infection than replicating smallpox vaccines. Cyclosporin may still reduce the immune response, and vaccination is often considered acceptable when exposure risk is significant.
How serious is the interaction between Cyclosporin and Smallpox and monkeypox vaccine live nonreplicating?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccination can be considered in immunosuppressed patients at risk of exposure, accepting that the response may be reduced. Consider additional doses or serologic assessment per local public health guidance.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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