Drug interactions
Cyclosporin + Somatropin
Severity: Moderate
Cyclosporin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone may increase CYP450 activity, which could lower cyclosporine concentrations. Data are limited, but cyclosporine's narrow therapeutic index makes changes important.
What this interaction means in plain words
Cyclosporin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Somatropin belongs to Endocrine.
Why it happens
Somatropin may induce CYP3A4 activity, increasing cyclosporine clearance.
What to do
Monitor cyclosporine trough levels when starting, changing or stopping somatropin and adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Cyclosporin with Somatropin?
MediHelp rates the interaction as moderate. Cyclosporin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone may increase CYP450 activity, which could lower cyclosporine concentrations. Data are limited, but cyclosporine's narrow therapeutic index makes changes important.
How serious is the interaction between Cyclosporin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels when starting, changing or stopping somatropin and adjust the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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