Drug interactions
Cyclosporin + Streptozocin
Severity: Major
Cyclosporin and Streptozocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and streptozocin commonly causes dose-related renal injury. Combined use may increase the risk and severity of kidney damage.
What this interaction means in plain words
Cyclosporin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity: cyclosporine causes afferent arteriolar vasoconstriction while streptozocin causes direct tubular toxicity.
What to do
Avoid the combination where possible. If unavoidable, monitor serum creatinine, electrolytes and urine protein frequently and hold or reduce doses if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Streptozocin?
MediHelp rates the interaction as major. Cyclosporin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptozocin commonly causes dose-related renal injury. Combined use may increase the risk and severity of kidney damage.
How serious is the interaction between Cyclosporin and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, monitor serum creatinine, electrolytes and urine protein frequently and hold or reduce doses if renal function declines.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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