Drug interactions
Cyclosporin + Sufentanil sl
Severity: Moderate
Cyclosporin and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise sufentanil concentrations and prolong its effects. This can cause excessive sedation and potentially fatal respiratory depression.
What this interaction means in plain words
Cyclosporin and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4, reducing sufentanil metabolism.
What to do
Monitor respiratory rate and sedation closely and reduce the sufentanil dose frequency if needed. Reassess when cyclosporine is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Sufentanil sl?
MediHelp rates the interaction as moderate. Cyclosporin and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise sufentanil concentrations and prolong its effects. This can cause excessive sedation and potentially fatal respiratory depression.
How serious is the interaction between Cyclosporin and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation closely and reduce the sufentanil dose frequency if needed. Reassess when cyclosporine is started or stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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