Drug interactions
Cyclosporin + Teniposide
Severity: Moderate
Cyclosporin and Teniposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase teniposide exposure and has been used as a chemosensitizer. This may increase myelosuppression and other toxicities.
What this interaction means in plain words
Cyclosporin and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits P-glycoprotein and possibly CYP3A4, reducing teniposide clearance.
What to do
Monitor blood counts closely and consider reducing the teniposide dose. Watch for mucositis and infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Teniposide?
MediHelp rates the interaction as moderate. Cyclosporin and Teniposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase teniposide exposure and has been used as a chemosensitizer. This may increase myelosuppression and other toxicities.
How serious is the interaction between Cyclosporin and Teniposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider reducing the teniposide dose. Watch for mucositis and infection.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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