Drug interactions
Cyclosporin + Tenofovir df
Severity: Moderate
Cyclosporin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and together they may increase the risk of renal impairment and tubular toxicity. Tenofovir exposure may also rise if renal function declines.
What this interaction means in plain words
Cyclosporin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity: cyclosporine causes afferent vasoconstriction and tenofovir causes proximal tubular injury.
What to do
Monitor serum creatinine, phosphate and eGFR regularly, and adjust tenofovir dosing for renal function. Consider tenofovir alafenamide or another alternative if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Tenofovir df?
MediHelp rates the interaction as moderate. Cyclosporin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and together they may increase the risk of renal impairment and tubular toxicity. Tenofovir exposure may also rise if renal function declines.
How serious is the interaction between Cyclosporin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and eGFR regularly, and adjust tenofovir dosing for renal function. Consider tenofovir alafenamide or another alternative if renal function declines.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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