Drug interactions
Cyclosporin + Testosterone buccal system
Severity: Moderate
Cyclosporin and Testosterone buccal system: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgens have been reported to raise cyclosporine concentrations, with an increased risk of cyclosporine toxicity including nephrotoxicity. The evidence is mostly from case reports and with other androgens.
What this interaction means in plain words
Cyclosporin and Testosterone buccal system can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of CYP3A4-mediated cyclosporine metabolism by testosterone; mechanism not firmly established.
What to do
Monitor cyclosporine trough levels and serum creatinine after starting or stopping testosterone, and adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Testosterone buccal system?
MediHelp rates the interaction as moderate. Cyclosporin and Testosterone buccal system can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgens have been reported to raise cyclosporine concentrations, with an increased risk of cyclosporine toxicity including nephrotoxicity. The evidence is mostly from case reports and with other androgens.
How serious is the interaction between Cyclosporin and Testosterone buccal system?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and serum creatinine after starting or stopping testosterone, and adjust the cyclosporine dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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