Drug interactions
Cyclosporin + Tetanus toxoid adsorbed or fluid
Severity: Minor
Cyclosporin and Tetanus toxoid adsorbed or fluid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can blunt the antibody response to tetanus toxoid vaccination. Protection may be lower or shorter lived in treated patients.
What this interaction means in plain words
Cyclosporin and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcineurin inhibition reduces T-cell dependent antibody responses to vaccines.
What to do
Give the vaccine on schedule since it is inactivated, ideally before starting cyclosporine; consider checking antibody titers or giving boosters for wound management as indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as minor. Cyclosporin and Tetanus toxoid adsorbed or fluid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine can blunt the antibody response to tetanus toxoid vaccination. Protection may be lower or shorter lived in treated patients.
How serious is the interaction between Cyclosporin and Tetanus toxoid adsorbed or fluid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine on schedule since it is inactivated, ideally before starting cyclosporine; consider checking antibody titers or giving boosters for wound management as indicated.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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