Drug interactions
Cyclosporin + Tezacaftor
Severity: Moderate
Cyclosporin and Tezacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine, a moderate CYP3A inhibitor, can increase tezacaftor exposure, raising the chance of adverse effects. The tezacaftor/ivacaftor regimen requires dose changes with such inhibitors.
What this interaction means in plain words
Cyclosporin and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4 metabolism of tezacaftor and ivacaftor.
What to do
Reduce the tezacaftor/ivacaftor dosing frequency per labeling for moderate CYP3A inhibitors and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Tezacaftor?
MediHelp rates the interaction as moderate. Cyclosporin and Tezacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine, a moderate CYP3A inhibitor, can increase tezacaftor exposure, raising the chance of adverse effects. The tezacaftor/ivacaftor regimen requires dose changes with such inhibitors.
How serious is the interaction between Cyclosporin and Tezacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the tezacaftor/ivacaftor dosing frequency per labeling for moderate CYP3A inhibitors and monitor for adverse effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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