Drug interactions
Cyclosporin + Turmeric
Severity: Moderate
Cyclosporin and Turmeric: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Turmeric and curcumin may inhibit CYP3A4 and P-glycoprotein and could raise cyclosporine concentrations. Evidence is limited and variable, but cyclosporine has a narrow therapeutic index.
What this interaction means in plain words
Cyclosporin and Turmeric can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Curcuminoids may inhibit intestinal and hepatic CYP3A4 and P-glycoprotein.
What to do
Avoid concentrated turmeric or curcumin supplements, or monitor cyclosporine trough concentrations and renal function if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Turmeric?
MediHelp rates the interaction as moderate. Cyclosporin and Turmeric can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Turmeric and curcumin may inhibit CYP3A4 and P-glycoprotein and could raise cyclosporine concentrations. Evidence is limited and variable, but cyclosporine has a narrow therapeutic index.
How serious is the interaction between Cyclosporin and Turmeric?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concentrated turmeric or curcumin supplements, or monitor cyclosporine trough concentrations and renal function if they are used.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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