Drug interactions
Cyclosporin + Typhoid polysaccharide vaccine
Severity: Minor
Cyclosporin and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Typhoid Vi polysaccharide vaccine is inactivated, so cyclosporin does not create a vaccine-infection risk. Antibody response may be diminished, giving less protection.
What this interaction means in plain words
Cyclosporin and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcineurin inhibition reduces immune responses to vaccine antigens.
What to do
Vaccinate if travel or exposure is expected, ideally at least 2 weeks before exposure. Continue food and water hygiene precautions since protection may be incomplete.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Cyclosporin and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Typhoid Vi polysaccharide vaccine is inactivated, so cyclosporin does not create a vaccine-infection risk. Antibody response may be diminished, giving less protection.
How serious is the interaction between Cyclosporin and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate if travel or exposure is expected, ideally at least 2 weeks before exposure. Continue food and water hygiene precautions since protection may be incomplete.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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