Drug interactions
Cyclosporin + Zaleplon
Severity: Minor
Cyclosporin and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zaleplon is metabolized mainly by aldehyde oxidase with a smaller CYP3A4 contribution, so cyclosporine is expected to have only a small effect on its levels. Slightly increased sedation is possible.
What this interaction means in plain words
Cyclosporin and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Zaleplon belongs to Central Nervous System.
Why it happens
Cyclosporine may weakly inhibit the minor CYP3A4 pathway of zaleplon metabolism.
What to do
No dose change is generally needed; advise patients to watch for excess drowsiness or impaired alertness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Cyclosporin with Zaleplon?
MediHelp rates the interaction as minor. Cyclosporin and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zaleplon is metabolized mainly by aldehyde oxidase with a smaller CYP3A4 contribution, so cyclosporine is expected to have only a small effect on its levels. Slightly increased sedation is possible.
How serious is the interaction between Cyclosporin and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; advise patients to watch for excess drowsiness or impaired alertness.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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