Drug interactions
Cyclosporin + Zanubrutinib
Severity: Moderate
Cyclosporin and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases zanubrutinib exposure, raising the risk of bleeding, cytopenias, infections and arrhythmias. Zanubrutinib labeling calls for dose reduction with moderate CYP3A inhibitors.
What this interaction means in plain words
Cyclosporin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Zanubrutinib belongs to Oncology.
Why it happens
Cyclosporine inhibits CYP3A4 (and possibly P-gp), reducing zanubrutinib clearance.
What to do
Reduce zanubrutinib to 80 mg twice daily during coadministration and monitor blood counts and bleeding; resume the usual dose after cyclosporine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Cyclosporin with Zanubrutinib?
MediHelp rates the interaction as moderate. Cyclosporin and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases zanubrutinib exposure, raising the risk of bleeding, cytopenias, infections and arrhythmias. Zanubrutinib labeling calls for dose reduction with moderate CYP3A inhibitors.
How serious is the interaction between Cyclosporin and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg twice daily during coadministration and monitor blood counts and bleeding; resume the usual dose after cyclosporine is stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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