Drug interactions
Cyclosporin + Zavegepant intranasal
Severity: Moderate
Cyclosporin and Zavegepant intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits OATP1B3 and NTCP and may markedly increase zavegepant systemic exposure. Safety consequences of higher exposure are not well characterised.
What this interaction means in plain words
Cyclosporin and Zavegepant intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B3 and NTCP transporters reduces hepatic uptake of zavegepant.
What to do
Avoid zavegepant in patients on cyclosporine where possible, and use an alternative acute migraine therapy. If used, monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Zavegepant intranasal?
MediHelp rates the interaction as moderate. Cyclosporin and Zavegepant intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits OATP1B3 and NTCP and may markedly increase zavegepant systemic exposure. Safety consequences of higher exposure are not well characterised.
How serious is the interaction between Cyclosporin and Zavegepant intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid zavegepant in patients on cyclosporine where possible, and use an alternative acute migraine therapy. If used, monitor for adverse effects.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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