Drug interactions
Cyclosporine + Daunorubicin
Severity: Major
Cyclosporine and Daunorubicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits P-glycoprotein and can raise anthracycline exposure, increasing myelosuppression, mucositis and cardiotoxicity. It also adds immunosuppression and infection risk.
What this interaction means in plain words
Cyclosporine and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
P-glycoprotein inhibition reduces daunorubicin efflux and clearance, with additive immunosuppression.
What to do
Consider reducing the daunorubicin dose and monitor blood counts, cardiac function and infections closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporine and Daunorubicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Cyclosporine with Daunorubicin?
MediHelp rates the interaction as major. Cyclosporine and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits P-glycoprotein and can raise anthracycline exposure, increasing myelosuppression, mucositis and cardiotoxicity. It also adds immunosuppression and infection risk.
How serious is the interaction between Cyclosporine and Daunorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the daunorubicin dose and monitor blood counts, cardiac function and infections closely.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporin. The full list is on the Daunorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
