Drug interactions
Daunorubicin + Dengue vaccine
Severity: Major
Daunorubicin and Dengue vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine (Dengvaxia) is a live attenuated vaccine. In patients receiving myelosuppressive chemotherapy, immune response may be reduced and the vaccine virus could cause disease.
What this interaction means in plain words
Daunorubicin and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs vaccine response and permits live vaccine virus replication.
What to do
Avoid live vaccines during chemotherapy and until immune recovery, as advised by the vaccine labeling and oncology guidance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Daunorubicin with Dengue vaccine?
MediHelp rates the interaction as major. Daunorubicin and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine (Dengvaxia) is a live attenuated vaccine. In patients receiving myelosuppressive chemotherapy, immune response may be reduced and the vaccine virus could cause disease.
How serious is the interaction between Daunorubicin and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and until immune recovery, as advised by the vaccine labeling and oncology guidance.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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