Drug interactions
Cyclosporine + Gliclazide
Severity: Moderate
Cyclosporine and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may alter sulfonylurea effect, and sulfonylureas have been reported to affect cyclosporine concentrations, although the data are inconsistent. Cyclosporine itself can impair insulin secretion and cause hyperglycemia, which complicates glycemic control.
What this interaction means in plain words
Cyclosporine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; possible pharmacokinetic effects on metabolism and cyclosporine-related beta-cell toxicity may contribute.
What to do
Monitor blood glucose and cyclosporine trough concentrations when starting or stopping gliclazide, and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Cyclosporine with Gliclazide?
MediHelp rates the interaction as moderate. Cyclosporine and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may alter sulfonylurea effect, and sulfonylureas have been reported to affect cyclosporine concentrations, although the data are inconsistent. Cyclosporine itself can impair insulin secretion and cause hyperglycemia, which complicates glycemic control.
How serious is the interaction between Cyclosporine and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and cyclosporine trough concentrations when starting or stopping gliclazide, and adjust doses accordingly.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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