Drug interactions
Cyclosporine + Glipizide-metformin
Severity: Moderate
Cyclosporine and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine has been reported to alter sulfonylurea effects, with hypoglycemia described in some cases, and may itself impair glucose tolerance through toxicity to pancreatic islet cells. Cyclosporine concentrations may also change, and the direction of effect is inconsistent.
What this interaction means in plain words
Cyclosporine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; cyclosporine may inhibit hepatic metabolism of sulfonylureas, and it has diabetogenic effects on beta cells.
What to do
Monitor blood glucose closely and check cyclosporine trough levels when therapy is started or changed. Adjust the antidiabetic dose according to glucose results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Cyclosporine with Glipizide-metformin?
MediHelp rates the interaction as moderate. Cyclosporine and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine has been reported to alter sulfonylurea effects, with hypoglycemia described in some cases, and may itself impair glucose tolerance through toxicity to pancreatic islet cells. Cyclosporine concentrations may also change, and the direction of effect is inconsistent.
How serious is the interaction between Cyclosporine and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and check cyclosporine trough levels when therapy is started or changed. Adjust the antidiabetic dose according to glucose results.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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