Drug interactions
Cyclosporine + Glyburide-metformin
Severity: Moderate
Cyclosporine and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase glyburide exposure and its glucose-lowering effect, with hypoglycemia reported. Cyclosporine itself can also cause hyperglycemia and nephrotoxicity, which complicates diabetes control and metformin safety.
What this interaction means in plain words
Cyclosporine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits hepatic uptake transporters (OATP) and CYP3A4, raising glyburide concentrations; renal toxicity may raise metformin exposure.
What to do
Monitor blood glucose and renal function, adjust glyburide dose as needed, and check cyclosporine levels if therapy changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Cyclosporine with Glyburide-metformin?
MediHelp rates the interaction as moderate. Cyclosporine and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase glyburide exposure and its glucose-lowering effect, with hypoglycemia reported. Cyclosporine itself can also cause hyperglycemia and nephrotoxicity, which complicates diabetes control and metformin safety.
How serious is the interaction between Cyclosporine and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, adjust glyburide dose as needed, and check cyclosporine levels if therapy changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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