Drug interactions
Cyclosporine + Measles mumps and rubella vaccine
Severity: Major
Cyclosporine and Measles mumps and rubella vaccine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine suppresses T-cell function, so the vaccine response may be inadequate and live vaccine viruses may cause disseminated infection. Live vaccines are generally avoided in patients on it.
What this interaction means in plain words
Cyclosporine and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Calcineurin inhibition suppresses T-cell activation, reducing vaccine response and control of live attenuated viruses.
What to do
Avoid live vaccines during cyclosporine and for at least 3 months after stopping unless benefit clearly outweighs risk. Vaccinate beforehand where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporine with Measles mumps and rubella vaccine?
MediHelp rates the interaction as major. Cyclosporine and Measles mumps and rubella vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine suppresses T-cell function, so the vaccine response may be inadequate and live vaccine viruses may cause disseminated infection. Live vaccines are generally avoided in patients on it.
How serious is the interaction between Cyclosporine and Measles mumps and rubella vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during cyclosporine and for at least 3 months after stopping unless benefit clearly outweighs risk. Vaccinate beforehand where possible.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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