Drug interactions
Cyclosporine + Meclofenamic acid
Severity: Major
Cyclosporine and Meclofenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce renal blood flow, cyclosporine by afferent arteriolar vasoconstriction and NSAIDs by prostaglandin inhibition. This can precipitate acute kidney injury and may also raise cyclosporine levels and blood pressure.
What this interaction means in plain words
Cyclosporine and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxic hemodynamic effects from cyclosporine vasoconstriction and NSAID inhibition of vasodilatory prostaglandins.
What to do
Avoid the combination where possible; if used, monitor serum creatinine, blood pressure and cyclosporine trough levels, and use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Cyclosporine with Meclofenamic acid?
MediHelp rates the interaction as major. Cyclosporine and Meclofenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce renal blood flow, cyclosporine by afferent arteriolar vasoconstriction and NSAIDs by prostaglandin inhibition. This can precipitate acute kidney injury and may also raise cyclosporine levels and blood pressure.
How serious is the interaction between Cyclosporine and Meclofenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum creatinine, blood pressure and cyclosporine trough levels, and use the lowest NSAID dose for the shortest time.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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