Drug interactions
Cyclosporine + Mitoxantrone
Severity: Major
Cyclosporine and Mitoxantrone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase mitoxantrone exposure, potentially intensifying myelosuppression and cardiotoxicity. Additive immunosuppression also raises infection risk.
What this interaction means in plain words
Cyclosporine and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of P-glycoprotein and BCRP efflux by cyclosporine reduces mitoxantrone clearance, with additive immunosuppression.
What to do
Monitor blood counts and cardiac function closely, and consider reducing the mitoxantrone dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitoxantrone
Frequently asked questions
Can I take Cyclosporine with Mitoxantrone?
MediHelp rates the interaction as major. Cyclosporine and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase mitoxantrone exposure, potentially intensifying myelosuppression and cardiotoxicity. Additive immunosuppression also raises infection risk.
How serious is the interaction between Cyclosporine and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely, and consider reducing the mitoxantrone dose.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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