Drug interactions
Cyclosporine + Repaglinide
Severity: Major
Cyclosporine and Repaglinide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases repaglinide exposure, increasing the risk of hypoglycemia. Repaglinide labeling restricts the dose with cyclosporine.
What this interaction means in plain words
Cyclosporine and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 and OATP1B1 reduces repaglinide metabolism and hepatic uptake.
What to do
Use the lowest effective repaglinide dose, not exceeding 6 mg per day, and monitor blood glucose frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Cyclosporine with Repaglinide?
MediHelp rates the interaction as major. Cyclosporine and Repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine increases repaglinide exposure, increasing the risk of hypoglycemia. Repaglinide labeling restricts the dose with cyclosporine.
How serious is the interaction between Cyclosporine and Repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective repaglinide dose, not exceeding 6 mg per day, and monitor blood glucose frequently.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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