Drug interactions
Cyclosporine + Sacubitril-valsartan
Severity: Moderate
Cyclosporine and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan blocks the renin-angiotensin system and reduces aldosterone, while cyclosporine also tends to cause potassium retention and renal impairment. Together they can raise serum potassium and worsen kidney function. Cyclosporine may also raise valsartan exposure through transporter inhibition.
What this interaction means in plain words
Cyclosporine and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemic effects from angiotensin receptor blockade and calcineurin-inhibitor-related reduced renal potassium excretion, with possible OATP/transporter inhibition raising valsartan levels.
What to do
Monitor serum potassium and creatinine at the start of combined therapy and after dose changes. Reduce the sacubitril-valsartan dose or reassess therapy if hyperkalemia or declining renal function develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Cyclosporine with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Cyclosporine and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan blocks the renin-angiotensin system and reduces aldosterone, while cyclosporine also tends to cause potassium retention and renal impairment. Together they can raise serum potassium and worsen kidney function. Cyclosporine may also raise valsartan exposure through transporter inhibition.
How serious is the interaction between Cyclosporine and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine at the start of combined therapy and after dose changes. Reduce the sacubitril-valsartan dose or reassess therapy if hyperkalemia or declining renal function develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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