Drug interactions
Cyclosporine + Topotecan
Severity: Major
Cyclosporine and Topotecan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits both P-gp and BCRP, and co-administration has been shown to increase topotecan exposure, particularly oral topotecan. This may increase the risk of severe myelosuppression.
What this interaction means in plain words
Cyclosporine and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits P-gp and BCRP efflux transport of topotecan.
What to do
Avoid combination with oral topotecan. If IV topotecan is required, monitor blood counts frequently and reduce the dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporin + Topotecan Major
- Darunavir + Topotecan Major
Frequently asked questions
Can I take Cyclosporine with Topotecan?
MediHelp rates the interaction as major. Cyclosporine and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits both P-gp and BCRP, and co-administration has been shown to increase topotecan exposure, particularly oral topotecan. This may increase the risk of severe myelosuppression.
How serious is the interaction between Cyclosporine and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination with oral topotecan. If IV topotecan is required, monitor blood counts frequently and reduce the dose as needed.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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