Drug interactions
Cyclosporine + Triamcinolone
Severity: Moderate
Cyclosporine and Triamcinolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may raise corticosteroid exposure, while corticosteroids can alter cyclosporine concentrations. Both are immunosuppressive, so infection risk is additive.
What this interaction means in plain words
Cyclosporine and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 and P-glycoprotein inhibition by cyclosporine, plus additive immunosuppression.
What to do
Monitor cyclosporine trough levels and renal function when steroid therapy changes. Watch for steroid excess effects and infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Cyclosporine with Triamcinolone?
MediHelp rates the interaction as moderate. Cyclosporine and Triamcinolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may raise corticosteroid exposure, while corticosteroids can alter cyclosporine concentrations. Both are immunosuppressive, so infection risk is additive.
How serious is the interaction between Cyclosporine and Triamcinolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when steroid therapy changes. Watch for steroid excess effects and infection.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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