Drug interactions
Cyclosporine + Vinorelbine
Severity: Major
Cyclosporine and Vinorelbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase vinorelbine exposure. This can intensify myelosuppression and neuropathy, and both drugs are immunosuppressive.
What this interaction means in plain words
Cyclosporine and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits CYP3A4 metabolism and P-glycoprotein efflux of vinorelbine, with additive immunosuppression.
What to do
Monitor complete blood counts closely and reduce the vinorelbine dose if neutropenia occurs. Watch for infections and neurotoxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Cyclosporine with Vinorelbine?
MediHelp rates the interaction as major. Cyclosporine and Vinorelbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase vinorelbine exposure. This can intensify myelosuppression and neuropathy, and both drugs are immunosuppressive.
How serious is the interaction between Cyclosporine and Vinorelbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the vinorelbine dose if neutropenia occurs. Watch for infections and neurotoxicity.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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