Drug interactions
Cyproheptadine + Diazepam intranasal
Severity: Moderate
Cyproheptadine and Diazepam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a sedating first-generation antihistamine, and combining it with diazepam adds to drowsiness, slowed reaction time and impaired psychomotor performance. The effect is most important in older adults and in people who drive or operate machinery.
What this interaction means in plain words
Cyproheptadine and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from antihistaminic H1 blockade and GABA-A receptor potentiation.
What to do
Counsel the patient about additive drowsiness and advise against driving after dosing. Use the lowest effective doses and reduce cyproheptadine dose or timing if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Diazepam intranasal?
MediHelp rates the interaction as moderate. Cyproheptadine and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine is a sedating first-generation antihistamine, and combining it with diazepam adds to drowsiness, slowed reaction time and impaired psychomotor performance. The effect is most important in older adults and in people who drive or operate machinery.
How serious is the interaction between Cyproheptadine and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about additive drowsiness and advise against driving after dosing. Use the lowest effective doses and reduce cyproheptadine dose or timing if oversedation occurs.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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