Drug interactions
Cyproheptadine + Droperidol
Severity: Moderate
Cyproheptadine and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating antipsychotic that can also prolong the QT interval. Cyproheptadine adds sedation, and the combination may deepen CNS depression and impair alertness.
What this interaction means in plain words
Cyproheptadine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine D2 and histamine H1 receptor antagonism.
What to do
Monitor level of sedation and use the lowest effective doses. Check ECG and electrolytes in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Droperidol?
MediHelp rates the interaction as moderate. Cyproheptadine and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating antipsychotic that can also prolong the QT interval. Cyproheptadine adds sedation, and the combination may deepen CNS depression and impair alertness.
How serious is the interaction between Cyproheptadine and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of sedation and use the lowest effective doses. Check ECG and electrolytes in patients with other QT risk factors.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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