Drug interactions
Cyproheptadine + Encorafenib
Severity: Minor
Cyproheptadine and Encorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so exposure to sensitive CYP3A4 substrates may rise or fall. Cyproheptadine is not a well-characterised CYP3A4 substrate, so the clinical importance of this interaction is uncertain.
What this interaction means in plain words
Cyproheptadine and Encorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib; cyproheptadine's reliance on this pathway is not established.
What to do
No empirical dose change is needed. Monitor for changes in cyproheptadine effect or sedation after starting or stopping encorafenib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyproheptadine and Encorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Cyproheptadine with Encorafenib?
MediHelp rates the interaction as minor. Cyproheptadine and Encorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encorafenib both inhibits and induces CYP3A4, so exposure to sensitive CYP3A4 substrates may rise or fall. Cyproheptadine is not a well-characterised CYP3A4 substrate, so the clinical importance of this interaction is uncertain.
How serious is the interaction between Cyproheptadine and Encorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor for changes in cyproheptadine effect or sedation after starting or stopping encorafenib.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
