Drug interactions
Cyproheptadine + Esketamine intranasal
Severity: Moderate
Cyproheptadine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and cyproheptadine adds sedative effects. Combined use may increase drowsiness and impair psychomotor function after the esketamine session.
What this interaction means in plain words
Cyproheptadine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor sedation during and after esketamine administration, and advise against driving until the next day after a restful sleep. Consider holding cyproheptadine on treatment days.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Cyproheptadine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes sedation and dissociation, and cyproheptadine adds sedative effects. Combined use may increase drowsiness and impair psychomotor function after the esketamine session.
How serious is the interaction between Cyproheptadine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during and after esketamine administration, and advise against driving until the next day after a restful sleep. Consider holding cyproheptadine on treatment days.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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