Drug interactions
Cyproheptadine + Flurazepam
Severity: Moderate
Cyproheptadine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting hypnotic benzodiazepine with an active metabolite, and cyproheptadine adds sedating effects. The combination may increase daytime drowsiness, impair coordination and raise the risk of falls and accidents.
What this interaction means in plain words
Cyproheptadine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 receptor blockade.
What to do
Use the lowest effective doses and warn about next-day impairment. Avoid in older adults where possible and consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Flurazepam?
MediHelp rates the interaction as moderate. Cyproheptadine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting hypnotic benzodiazepine with an active metabolite, and cyproheptadine adds sedating effects. The combination may increase daytime drowsiness, impair coordination and raise the risk of falls and accidents.
How serious is the interaction between Cyproheptadine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn about next-day impairment. Avoid in older adults where possible and consider a non-sedating antihistamine.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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