Drug interactions
Cyproheptadine + Glycopyrronium tosylate
Severity: Moderate
Cyproheptadine and Glycopyrronium tosylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium tosylate is a topical anticholinergic for hyperhidrosis with some systemic absorption. Together with cyproheptadine it may cause additive anticholinergic effects such as dry mouth, blurred vision, constipation and urinary retention.
What this interaction means in plain words
Cyproheptadine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects such as dry mouth, urinary hesitancy and blurred vision. Stop or reduce one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Glycopyrronium tosylate?
MediHelp rates the interaction as moderate. Cyproheptadine and Glycopyrronium tosylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium tosylate is a topical anticholinergic for hyperhidrosis with some systemic absorption. Together with cyproheptadine it may cause additive anticholinergic effects such as dry mouth, blurred vision, constipation and urinary retention.
How serious is the interaction between Cyproheptadine and Glycopyrronium tosylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, urinary hesitancy and blurred vision. Stop or reduce one agent if symptoms occur.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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