Drug interactions
Cyproheptadine + Ketamine
Severity: Moderate
Cyproheptadine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine causes dissociation and CNS depression, and a sedating antihistamine can add to drowsiness and psychomotor impairment. The effect is usually manageable, but may be more pronounced in procedural or higher-dose settings.
What this interaction means in plain words
Cyproheptadine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor level of consciousness and respiratory status when both are given. Reduce doses as needed and advise against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Ketamine
Frequently asked questions
Can I take Cyproheptadine with Ketamine?
MediHelp rates the interaction as moderate. Cyproheptadine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine causes dissociation and CNS depression, and a sedating antihistamine can add to drowsiness and psychomotor impairment. The effect is usually manageable, but may be more pronounced in procedural or higher-dose settings.
How serious is the interaction between Cyproheptadine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and respiratory status when both are given. Reduce doses as needed and advise against driving.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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