Drug interactions
Cyproheptadine + Levorphanol
Severity: Moderate
Cyproheptadine and Levorphanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as levorphanol cause sedation and respiratory depression, and sedating antihistamines may add to these effects. The combination increases the risk of profound drowsiness and impaired psychomotor function.
What this interaction means in plain words
Cyproheptadine and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate, particularly at initiation. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Levorphanol?
MediHelp rates the interaction as moderate. Cyproheptadine and Levorphanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as levorphanol cause sedation and respiratory depression, and sedating antihistamines may add to these effects. The combination increases the risk of profound drowsiness and impaired psychomotor function.
How serious is the interaction between Cyproheptadine and Levorphanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate, particularly at initiation. Counsel patients to avoid driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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