Drug interactions
Cyproheptadine + Lofepramine
Severity: Moderate
Cyproheptadine and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic properties, as is cyproheptadine. The combination may increase drowsiness and anticholinergic effects such as dry mouth, constipation and urinary retention. Cyproheptadine's serotonin antagonism may also blunt antidepressant effect.
What this interaction means in plain words
Cyproheptadine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and anticholinergic effects; possible 5-HT2 antagonism of antidepressant action.
What to do
Monitor for sedation, anticholinergic effects and antidepressant response. Be cautious in older adults and those with glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Lofepramine?
MediHelp rates the interaction as moderate. Cyproheptadine and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with some sedative and anticholinergic properties, as is cyproheptadine. The combination may increase drowsiness and anticholinergic effects such as dry mouth, constipation and urinary retention. Cyproheptadine's serotonin antagonism may also blunt antidepressant effect.
How serious is the interaction between Cyproheptadine and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and antidepressant response. Be cautious in older adults and those with glaucoma or urinary retention.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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