Drug interactions
Cyproheptadine + Lormetazepam
Severity: Moderate
Cyproheptadine and Lormetazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so together they may cause marked drowsiness, impaired coordination and slowed reaction times. Older patients are at particular risk of falls and confusion.
What this interaction means in plain words
Cyproheptadine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects (GABA-A potentiation plus H1 antagonism).
What to do
Use the lowest effective doses and warn about driving and alcohol. Monitor older patients for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Lormetazepam?
MediHelp rates the interaction as moderate. Cyproheptadine and Lormetazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so together they may cause marked drowsiness, impaired coordination and slowed reaction times. Older patients are at particular risk of falls and confusion.
How serious is the interaction between Cyproheptadine and Lormetazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and warn about driving and alcohol. Monitor older patients for oversedation and falls.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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